Coffee is a major traded item worldwide. Uganda, where the coffee sector provides a livelihood to 1.8 million households, is Africa’s second-biggest coffee exporter. Pests and diseases are significant constraints affecting coffee production. Although the Ugandan government has implemented strategies to assist farmers in addressing these constraints, coffee pests and diseases continue to affect the yield and quality of coffee crops. This ongoing issue highlights the need for more effective and sustainable solutions to protect coffee production in Uganda. This review examined two prevalent diseases and two major pests known to significantly impact Uganda’s coffee systems. It explored strategies that pathogens and pests would utilize to invade and colonize coffee plants. Furthermore, this review evaluated current challenges and prospects for improving coffee pest and disease management. By offering valuable insights and recommendations, it aims to equip agricultural stakeholders with the knowledge needed to develop and implement more effective strategies for combating these persistent threats to coffee production in Uganda.