This article aims to compile key information to describe the current production situation of potatoes f or c onsumption and v irus- free s eed potatoes i n Paraguay, and to identify the main challenges for developing a self-sufficient production system. The study describes the climatic conditions of the production of potatoes and the national production and distribution situation, highlighting the dependence on imports for more than 90% of market demand. It analyzed the issues surrounding the production and supply of virus-free seed potatoes, which depend on imports from Argentina, averaging 799.9 tons per year. Additionally, this study collects information on virus detection in local potatoes and the risks associated with introducing viruses through imported seeds. To address these issues, the Korea Partnership for Innovation of Agriculture (KOPIA) and the Paraguayan Institute of Agricultural Technology (IPTA) cooperation project promoted the production of virus-free seed potatoes for their distribution to smallholder farmers across various country regions, strengthening the foundations for future virus-free seed potato production and distribution systems. Improving self-sufficiency in potato production in Paraguay requires an integrated strategy that includes analyzing suitable regions for seed potato production, implementing advanced technologies, and strengthening farmers’ technical capacity. Establishing virus-free seed potato production areas and securing governmental and legal support are crucial steps toward achieving sustainable seed potato production and reducing dependence on imports.